Pharmaceutical Drug Development Process Explained by Medical Expert

[00:00:00]this week on Dr Drew after dark this is how how pharmaceutical research works from the moment you pull a molecule off the shelf and identify it you have 10 years to bring it to Market and profit and then you lose the patent why did you think we would like that call yeah also I really hope we just assisted with only a book right yeah it should be tracing that call you guys like Macabre but I I went a little more of a cop than I expected [Music] thank you [Music] welcome Dr Drew after Dark please be advised that Dr Dre after dark may contain sexually oriented content and be unsuitable for young children hey everybody Welcome to doctor after dark phone number 818-253-1693 the email is Dr ARCA gmail.com everybody it's me and the booth boys gentlemen ladies what's going on in there what's up hello look at Heather in the house Heather is this your this is your first time on this yes uh in the booth for this show yeah usually um not today pal weren't you on the booth when we were in Annie's house and you were talking about uh oh my tumor yeah what yeah isn't that like one of your first days that was like my first day and and Drew you were like hey like you should come on the show and so I talked about the tumor that I had removed from my spine I don't remember talking about that well tell me to tell us again really quickly yeah so I had a Teratoma that was on my tailbone and didn't know until they took it out um yes so pretty I think we grossed everybody out with descriptions of what a Teratoma is right yes because it has skin cells teeth cells hair cells all kinds of stuff think about it guys it's she was growing a monster in her tail no no it's that's teratoma is the teratology is is monstrous it means a monster and so it's literally every amp teratoma I named it Winnie why Too Close why just because I I wanted to call it something I was like get out of me dude I wanted to call it something what fine ones with like you'll see them with like eyeballs and teeth and no keep going down uh let's see here keep going hair oh there's a good one on the second one yeah that looks kind of like some nasty [ __ ] in there yeah any tissue can grow in a Teratoma it's a monster uh yeah look at that a scalp what teeth look at that fully formed teeth yeah the biology is awesome and so did you were you having pain or something yeah I started having pain um and then noticed that there was a bump back there that was probably growing for a really long time and then they removed it but I'm still like dealing with all kinds of chronic pain after that I'm sorry yeah but we figured it out got a medication that helps with my nerve pain and what is that like Gabapentin or something uh no it's a Nortriptyline oh interesting good for you so that's been helping sleep too dry mouth yeah nasty it's an old-fashioned tricyclic antidepressant but has lots of other properties wouldn't it be cool though if uh during Potters little surgery I did if I sort of found a Teratoma in there it would make sense wouldn't it cool I don't know if you're not cool yeah that stuff should give me the creeps at all uh monsters in your in your house yeah a little bit it's a little concerning yeah it's a little it's good it's adjacent to your area of concern you know what I'm saying like I know this energy with hmm they look like like Cronenberg creatures yeah very wild crazy all right let me uh let's do a little bit of uh email we got some voice uh we got some phone calls coming in I'm gonna get right to those calls guys hanging I'll be right with you I just want to do a couple emails first here we are I have an irregular Corpus cavernosum issue okay give me a penis and cross-section one side is twice as big as the other the smallest side has a Bend about halfway up the penis also I pressed into my pelvis the base penis feels like a kink in the hose just curious if uh I'm in an area that pushes surgery and the information I find online is a bit all over the place mostly pointing to enhancing size uh over correcting as issue okay so that second one from the top there there we are uh then the the red little spongy things in the middle there that's the Corpus cavernosum uh that's what swells up during an erection right and he's saying that one side is shorter than the other I I would be it's possible but I wouldn't be surprised if what actually is happening you just have a a contraction of the sheath around one of them which is peroni's where you get a contraction that pulls it over to one side and that kind of Peyronie's sometimes needs surgery what they're also suggesting what you're reading about is putting a like a extender in one side you know that you can inflate when you get erections which is another possibility but if it's peyronies that would cause pain so you got to see a urologist about this who does this sort of thing I had to bring in this urologist I work with a female urologist that does a lot of implants and stuff we had to might bring her in there it might be interesting I I think yeah Ashley Tapscott is her name to look her up there and uh she she's very entertaining as Ashley tapsco yep there she is that's Ashley and she spends all day putting in penis implants that's what he does all day yeah I've talked to her a couple times on my streaming show all right so good there we go uh email one more before we go pregnancy poundings my wife is 32 30 weeks pregnant cervix shortened and had to get a circlage gentlemen sir collage please please spelled it very I'm not sure if he spelled it right I think it's the IR yeah I think it is circlage um there it is see what's going on there they sew the cervix it's kind of they kind of sew the baby in by serving by closing the cervical off with it with a with some sutures essentially or wires uh let's see uh the strip collage put in at 21 weeks keep the baby from coming out my wife got me a pocket [ __ ] to hold me down oh it's your mom's house uh but not it's not the same my question is will we cause damage if I penetrate a few inches into the V uh but stopping before she orgasms what are the effects of having sex while having a sir Clause you know I don't know it's an interesting question I I'm sort of pissed that your uh obstetrician didn't say don't have sex if you're not supposed to have sex for the most part you can have uh sex all the way through a pregnancy all the way in the third trimester no problem but uh I I don't think it would be a problem but you've got to talk to your obstetrician about that all right I'm gonna talk to Amanda here Amanda what's going on hey Dr Dre I had a quick question yeah so in April it looked at normal but I was in intense pain afterwards where it was so intense where I couldn't walk where was the pain pelvic pain in my pubic bone pubic bone okay like was it like a pressure or stabbing or sharp how would you describe okay the pain continued for about two years wow and no doctor could tell me exactly why Wow then the pain subsided after the two years and I got pregnant with my daughter in July of 22.

[00:07:48]um I didn't feel any pain throughout my pregnancy until I was about five months pregnant the pain was back and it was the same pain I had felt in the past my OB GYN then sent me to an orthopedic surgeon who took an x-ray at me of about 35 weeks pregnant I think wow and told me I had a separation of my pubic bone that's what it sounded like to make yep wow and and see the reason it the symptoms kind of go away is when you're pregnant you get this hormone called relaxin and so that separation kind of relaxes a little bit but then it starts to separate more when the baby gets big oh boy okay so after I I told me I had a separation I delivered her in April and the delivery was extremely painful oh my God yes the epidural didn't take away bone pain oh I'm amazed they didn't do a C-section on it would you do you refuse to see the C-section or something they said it would make it worse okay I don't see how but I have her naturally yeah well I'm actually still need now yeah it's been she's four months now yeah and I'm kind of stuck because do I not have any more kids you know because this is going to happen again or do I wait longer in between maybe if I wait a couple more years it's not such a quick question it's not an easy question either I I some it's sort of philosophical right because it is going to happen again uh the question is how much are you willing to go through and I what I would also I I am certainly no expert in pubic you know give me a pelvic bone just pelvic bone up there uh and you know I think everyone knows where the pubic bone is but there's a connector there yeah just any of those are fine uh yeah you see the where the sort of rings come together there that's the pubic bone and there's a right and there's a joint there essentially and that can separate it's kind of unusual but I I and it should kind of heal on its own the pelvis does tend to heal on its own I I here's what I would do I I would go back to the orthopedist and and establish this question if I keep doing pregnancies which I know are going to be painful again am I going to do permanent damage and could I end up with a permanent problem here because that you don't want to do okay you've got to talk that orthopedist how are the babies yeah they the babies are healthy the babies are healthy it's just I have a hard time keeping up with them unfortunately well isn't too enough I've done when I was pregnant is it too enough you gotta have more well I wanted six oh my god well you may want six but God may have had other plans for you you and and me and and by the way they as they always say he gives you what you can tell what you can take and maybe this is it maybe he's telling you something but I would go and and three is I I had three three is a lot man it gets a lot different at three uh and four five and six you can start to use the kids to help with the other kids but I'm just saying uh so again get back to that orthopedist find out if this is going to be permanent damage find out if there's any treatment you can initiate that might reduce the risks of what happens during pregnancy but I'm suspicious they're gonna here's what I suspect they're gonna tell you but I suspect they're going to tell you is yeah it's going to get worse yeah it's going to hurt could do permanent damage they're going to go oh yeah we don't know for sure but you could be in pain the rest of your life that's what they're gonna they're gonna say something like that I bet all right oh yeah all right yeah thank you so much I bet but I'm don't take my word for it go make sure that they they actually go and have proper consultation okay okay thank you so much all right Amanda good luck that's an interesting car I love these ones where they're not stuff I've seen or used to hearing about Falls here and if you're excited about the new season you'll want to feel your best thank you to today's sponsor manscaped thanks to manscape you can be prepared for anything this Autumn head over to manscape.com use the code after dark for an exclusive 20 off discount and free shipping so let me tell you about manscape they can boost your confidence you probably heard about them by now but it's time to join the 9 million plus man worldwide who have trusted manscape and invest in their all-encompassing performance package 4.0 they think of everything and they're just careful with their products first up the lawnmower 4.0 trimmer featuring Advanced Skin safe technology this revolutionary Tech minimizes Nicks and cuts making grooming as painless as possible wherever you want to groom after you've tidied up the driveway the performance package has you covered with the products to keep you feeling fresh there's the crop preserver ball deodorant and crop reviver ball spray a toner designed to prevent and eliminate unpleasant owners both contained a soothing aloe vera formula that everyone can appreciate and prevent that chafing bring in the fall right and get 20 off and free shipping with our code after dark at manscaped.com m-a-n-s-c-a-p-e-d that is 20 off with free shipping at manscape.com and use code after dark as the leaves fall make sure you have it all with manscaped getting a shape can be hard but I understand the importance of maintaining a balanced diet even during our hectic fall season but who has time to spend hours in the kitchen that's where hello fresh comes to the rescue with hello fresh you can enjoy a wholesome meal without sacrificing precious time say goodbye to the endless hours in the kitchen because hellofresh offers quick and easy recipes 15 minute meals also that have a delicious dinner on your table in no time you can have your meal ready faster than you can order takeout or order delivery hello fresh takes the stress out of meal planning out of shopping they deliver fresh high quality ingredients right to your doorstep no more last minute trips the grocery store this fall we've got you covered with hellofresh embrace the new season with hello Fresh's exciting fall lineup of mouth-watering dinners and more selection of over 40 weekly recipes tailored to your lifestyle whether you're a veggie lover a whole family to feed or looking for fit and wholesome options there is something for everyone rest assured that when you choose hellofresh you're receiving top-notch produce the ingredients travel from the farm to your door in less than seven days ensuring you the freshest flavors with every bite it's America's number one meal kit here to make your fall season fit fresh and fantastic I love the parmesan crusted Cod and the chicken parm salad hello fresh makes cooking so easy and fast my son Jordan prepared it for me when Susan was away go to hellofresh.com 50 Dr Drew that's number 50 Dr Drew and use code 50 Dr Drew for 50 off plus 15 off the next two months again go to hellofresh.com 50 Dr Drew and use code 50 Dr Drew that 50 off and 15 off for the next two months whoops I'm gonna get bad up there Ben what's going on buddy hey Dr Drew how's it going we're good what's happening well um I had a question about my white um my wife and I've been trying to get pregnant for about a year and a half with no success and he sent me to have a semen analysis done and it came back that I was pretty much very low on every metric um so I just wanted to see get a baseline from you if we did nothing at this point like what are the chances of us getting pregnant naturally you have to ask are you seeing a fertility specialist um I started to yeah we haven't gone you know gotten the initial appointment yet okay so the you're you're you you need to do that I I don't know exactly what the thresholds are there's a certain number that if you drop below I think it's a is it a million I forget what the number is but there's a number if you drop below the risk that the probability of pregnancy goes way down and then if you also have motility issues or capacitation issues on top of that that then you're sort of in difficult territory the real question is why why is this happening did they do any evaluation the only thing they've done is the semen analysis so far um and the normal range they gave me was 15 million per milliliter and I'm at 8.2 and the motility the normal range was forty percent I'm at 13 yeah so there's still more progression motility was it seems to me I don't again it's supposed to be like 32 I know throughout my day evaluating these numbers but it seems to me like there should still be some probability of pregnancy it's just you need to you need to enhance that probability but but what's going on did they check a testosterone level for you um I think that's probably the next step the issue is my insurance doesn't cover a fertility treatment yeah but that's a but that's a medical thing dude that's Medical on the website yeah and that's another thing if you have American skills or sister seals they can take those out that can help in enhanced sperm production or sperm delivery at least and to stop measuring your testosterone is a medical question that's not no that's not fertility that has to be answered medically why do you have if you have low testosterone why do you have low testosterone I will tell you the most common reason for all of this is uh medication and substances so are you drinking a lot are you smoking a lot of weed are you want any medication um I'm not on any medication um I don't do drugs never done drugs um I drink maybe once every two weeks or so all right well that's not it then so this needs to be explained that needs to be explained there's still a probability of pregnancy it seems to me based on these numbers again no expert here on that but uh it is uh you know when you go to the fertility specialist it's going to be all out of pocket is that correct uh it seems to be that way yeah so tell them right away look we want to kind of go easy here are there things that we can do that aren't going to cost a lot of money you start make that clear to them up front because right because you can get into really nasty expenses so quickly with fertility treatments it's a really kind of a pain yeah um and they gave me a list of vitamins to start taking good um so I'm going to do that and see maybe if that helps but good and where uh let your let your balls dangle a little bit more right helps you make the white if you don't use the Tidy whities I thought I was all right all right good all right my friend thanks for the call really interesting uh let's talk to uh Becky some good questions Becky what's going on there [Music] Jackie what's up um so I um where do I start I want to make this as concise as possible but I need to thank you first and foremost I've wanted to for a long time for helping end my marriage um I know it's a weird thing to say I hope it was a good thing back in the day when you start show yeah what's that keep going we started the show um you you you started the show with Canadians watching the crazy videos and Tom and Christina wanted to identify if it was meth or mental illness yes and I got a real charge out of that and was laughing my ass off for a long long time until it hit me one day oh my God you're describing my husband oh boy yes so was it was it was it math or what was it math or mental illness it was a little almost says plural um he was diagnosed bipolar by a psychiatrist and then we got into couples therapy and our lmft um saw the Expressions multiple time of BPD as well as NPD but the obviously the BPD more so so let me just stop you for people hang on it's a narcissistic personality disorder and borderline personality disorder these are the cluster B types not fun to be around especially with the bipolar disorder on top of that no usually those guys do drugs is he doing any substances also uh well when we first started dating um I feel like I gave him the road map to how to lie to me because I told him on our first date that hard drugs were a hard pass that's a hard deal breaker for me and he just told me not a problem and then in a major fight about a year into the relationship he threw in my face that he'd been doing cocaine behind my back the entire time there you go they do not disappoint they do not disappoint people with those disorders and by the way to their they suffer they suffer as much as you do you know what I mean I'm sure you saw that with him the these disorders are not fun to have they are not fun they're often to be around they're not fun to have no and I was 19 when we got together and so I was very naive so I couldn't sorry it's still emotional I'm sorry um I'm sorry it's it we ended up getting married and I had two children with him and so I'm sorry so now it's how do I co-parent with this person especially now that he has a new girlfriend who just moved in and she has no clue that he has these things because he doesn't see the psychiatrist anymore so he doesn't take the meds and he refutes he refutes the other diagnoses because he hated the therapist because she called a spade a spade and she finally saw through well let's let's remind ourselves and when people have those diagnoses one of the reasons they're nearly impossible to treat is they always feel that way they all what they always feel is I know they don't they can't look inside for the solutions because the problems are all out there it's you you're the problem so why would I you know there there it is and uh and they're very shame avoidance and stuff and it's very very difficult for them to look at things because they're just they can't they can't experience these feelings uh they're sort of like Teflon with that stuff okay so um obviously in a structured away as possible correct um well here's the other thing about uh his Psychopathology is that people find each other you know what I mean and uh there's a reason she's with him she's gonna have her own stuff you whatever was going on with you you sort of recovered from and you sort of came to and you sort of made some healthy choices for yourself and you're not chronically in whatever that state was that that fit with him at the at the time which might have just been adolescence right adolescents all have sort of personality disorders yeah and so it might have been just that or was things nasty at home at the time uh yeah yeah so that's sort of a typical thing I mean I know I don't I don't it's him and tell us just so people have so P so people can so people can hear what this how this works why were you with him oh uh well there's a child um my father was absolutely horrible um I watched him physically abuse my brothers and he verbally and mentally abused me um so ultimately I ended up marrying my father right which is so ridiculously on the nose because that's what you always hear and of course as a kid as an adolescent you go I'm not going to turn into my parents and yeah it [ __ ] happens there it was yeah it's it's people never talk about where attraction comes from if you have childhood drama it becomes the source of Attraction you become attracted to people and circumstances that are just like the original perpetrators we don't know why that happens it's some wiring in our head they must have had some evolutionary adaptation to it at one time in his in human evolution it it's totally it does not serve us well now but but the good news is you you didn't develop a personality disorder you just developed this kind of codependency and so you were able to kind of recover from that and rework your attraction maps and it no longer worked for you and you pulled out this girl that's with him now maybe have may have some stuff going on right some real stuff in which case let them do their thing you don't don't it's not your responsibility how do I co-parent ah especially now that worry about her because he is drawn to stable people which I do understand and I maybe logically get maybe it's still maybe it still hurts maybe let's hope that will be the best scenario that'd be the best case that'd be the best case the the other the other version of that is they could be a volatile explosion all the time uh and they could be attracted to that in each other and that that's what you have to watch out for with the kids I I would uh how old are the kids now nine okay so I'm not worried so much about my son because I've been able to have discussions with him because he unfortunately has has experienced firsthand just a couple times since we split what the borderline personality disorder looks like and you know we've had to have crying sessions where he's crying on my shoulder and you know asking questions now he sees a therapist as well she's incredibly helpful great oh my God you're you're so this is this is well this is Wonder this is a great story you're telling right this is how things get how people end the cycles of abuse this is how people get better this is how people thrive treatment does work the personality disorders they're gonna have to do their thing and hit their bottom in their own way and whatever uh but but your stuff this is uh terrific I mean it's your daughter I mean you've got your son in the house so he can you can maybe get him to kind of keep an eye out for what's going on there and uh does she have her own therapist too or she does she doesn't She's So Young I'd love her to see the therapist that my son and I see we see her separately not not in the same session I get it she is wonderful but she doesn't specialize in young children yeah you're doing abs I'm not worried about you you're you're doing everything right and whatever you think is the right thing to do is the right thing to do okay just stand up for yourself set limits trust your instincts that's what you got to do and get and get um I worry about this woman considering herself mother to my children well that's every you know ever that's that's every co-parenting situation right everybody worries about that stuff and uh just just stay connected to your kids and remember don't forget this too they love their father right he has pathologies they love their father drives me crazy it's okay if it doesn't seem fair it's like I understand of course they love him but it's like to see what part of the reason why I got divorced is because when I finally realized what was going on it's like I need to end this so I don't exemplify this to the children and now here we are he's just he got together and started dating two days after the divorce was final but it's very different relationship with this woman and now they're going to see it over there it's very different though than them doing that him doing that to their mother their mother's standing up for themselves setting limits getting out that is a very different situation than one then then he just looks pathological you know because kids have this fantasy that families are going to stay together it didn't work look this is him now this is what he does in relationships they'll see it but you do have to worry about your daughter because so she doesn't get imprinted with all this right so you know say she needs to be around her dad so he's not abandoning but it needs to be very very structured very very structured okay well that's the only other problem is that when they're together he spends all of his time with my son they are into one hobby together um and he leaves her in front of the television screen and so I feel that she you know when he doesn't come through for stuff she goes okay whatever well when it's with my son he's hurt he's hurt by that so like I see that disconnect already but but you're right that's not it neither is a good thing neither is good but I I would keep your son on looking out for stuff and I would talk to your husband he's not a he's not an Iran I mean he's not a dumb person so you can appeal to him and go hey she's she is needs more from you I as a woman can tell you that okay just be real clear with him yeah don't don't walk on eggshells you don't have to do that anymore like I totally do because if I say anything wrong it's he's and then I'm all of a sudden even though I've proven completely otherwise right that's the liar I'm a you know everything is just so extreme that's the borderline stuff so so the trick is to keep him glued together and don't expose him to shame if you can avoid it uh and just be you know matter of fact about everything just but don't walk on eggshells you don't okay all right thanks for the call very good good work let me uh we're gonna try something uh a little new here we are going to look at some medical videos and I'm actually very very excited about this is it just medical videos today or do we have any uh is it tick tocks is that what they are they're all they look like medical videos I think they're mostly from Tick Tock okay yeah this will be very interesting we've done this a bit on social media but I wanted to bring this in to after dark because we should be doing this here so here we go uh what do you got let's see it again we sometimes have to look at these uh okay so what I think is going on and what does she have on her nails can you can you freeze it with the hand up there we go what does she have are those can you guys see what's on those Nails I think they're painted are they is there something wrong with her nails yeah her fingers on the ends are like they're kind of clubbed you know I see that and interesting you would use that word so clubbing does happen her thumb there on the r left her right looks especially clubbed and that can be from low circulating oxygen and from you know sort of these cardiac issues and things um the nails themselves don't look normal I'm wondering if excuse me I'm wondering if whatever that is whatever she's put on the nail or in the nail is obviously causing a reaction in the nail bed that's what she's pointing at there and the fact that they're soft means that they're probably filled with pus I mean those are probably peri-angle abscesses that she is just turned her fingernails into just abscesses if they're not they're at least fluid in their inflammatory fluid and uh you can get that from certain autoimmune diseases but it doesn't look like this so I I think she's a those are going to be like literally lanced I cut open and drained and those whatever it has on her nail is going to have to come off could this uh is that definitely the case that it's liquid or is that um could this be an aesthetic thing because have you seen how they do that with their the forehead the the donut forehead no can you show me donut forehead what yeah you can well I think I think they're she's obviously thinks this is cool because she's not saying what the hell's going on here she's saying you know the how about this uh I I she may be going for it but I'm telling you that that is going to be problematic that it could all be just inflammatory it doesn't have to be pus but it just uh it it's that is donut forehead what is that oh my God what is it so they I don't know if it's if it's oh saline injections oh yeah saline injections to purposefully make their foreheads look like a [ __ ] donut this is an aesthetic like Choice does it stay that way for a long time yeah how did you bagel head it says bagel head is a type of body modification pioneered in Canada oh my gosh so I don't know it's like that that's where my mind goes is like did she [ __ ] inject something in there uh make her fingers on purpose it's not impossible is it enough it's possible uh but it's just bagel head Trend in Japan I like the way they call it bagel head we made it donut head they're calling it bagel head uh wait wait wait wait look at that Japanese bagel has most extreme Beauty Trend the video can we play that video is it can we get away with that oh my gosh body modification blah blah blah oh here we are Japanese bagel heads and he's and you said it's sick oh my God they're holding Donuts up to their head what is I wonder where it came from uh what you got sticking out of it oh they're putting the needle in I see what's wrong with human beings what is oh I see they I see what they do yeah yeah oh so they just put it okay so that's not permanent they they put in a bunch of fluid of some type and then they Dent it with their thumb what what is coming oh it's an infusion oh my God it's a Salient if you infusion because that because it requires a fair amount of fluid in there I like the way they're like admiring it like oh I'm so beautiful with my bagel head it says six to 24 hours it's absorbed into the body yeah it gets absorbed how did you hear about this check that out see he's got it on his [ __ ] arm yeah oh interesting well yeah I was gonna say that that beats putting beads under your arm and stuff I'll sign off on that if you have to have something under your skin uh oh white guy with it that's interesting and uh they're but they're putting them on both sides almost like horns now too that's interesting oh a bunch of uh is it that's [ __ ] just Japan though is it just Japan oh no what's this we're watching a procedure here uh the results of uh oh my god look it went over the guy's eye can that do like any sort of damage to your skin you know I I would think it could cause scarring over time uh but I don't know maybe it would reduce the risk of wrinkles or increase the risk I don't know but who thought of this where did it come from I I just to me it's okay I've had enough all right well there you go uh how did we get to bagelhead what were we talking about that girl's fingertips I was wondering fingertips it could have been I guess I I you know you guys as always uh humans never cease to amaze me that I mean I'm glad I spent time in your mom's house I learned about uh you know our cool guy Mal's and Tick Tock eyes and now we've got uh what do we call this you know we got donut heads donut heads donut heads that's what we'll call it give me another one okay me and my weird medical mystery every time I stand up I fall down well that's POT Syndrome is that it at the end of the video yeah oh she puts her hands up because that's what it really well that makes sense do you see her fall let's see no which is why I'm gonna say pretty sure this is cat right sus yeah this is good to me on Tick Tock [ __ ] out here all right another video [Music] every time I kiss a new guy I get a sore throat and allergic to man no but I've heard of it oh she's she is that a is that that's a woman yes a girl yeah is this her pronouns anywhere uh and was she making uh oral sex move there was she was that part of what her little movement thing was like is that part of what I've heard of people giving oral sex to men and getting these uh sore throats see there is that a isn't that a oral sex move there I think it's just a goofy Tick Tock Dance all right fair enough uh and I don't it's not allergy when people get this I'm not sure what it is I've heard of it before I've heard it from kissing of her from oral sex it's I I don't know if the if it's the body fighting off infection and I've seen some people actually get these really like significant sore throats afterwards where they have to take antibiotics I don't know I do I do know what happens I don't know why it happens uh I don't know I have a potential hypothesis all right I'm ready she's gay right that's first that's that's what that is she's gay she's allergic she doesn't like men she's lesbian so every time she kisses the guy she has a reaction you not everything is in the head my friend I know yes everything is I'm not sure about that uh it's an interesting idea I do I do as you know I do put a lot of uh emphasis on the brain and it's you know it's effect on the body I'm with you on that but I've heard of this from people that are really super straight for sure so that's [ __ ] enough all right good I never know with you dude and if I didn't take you seriously I don't know yeah nobody does no one knows it's good you're good at it it's us all right thank you I was taught by the best give me another one then I'm gonna go to some calls oh no well that could be a lot of stuff so she has a fine Tremor in both hands uh when she holds you know it's it's a that typically that kind of shakiness is uh drugs medication actually named drugs medication uh and or familial drummer uh benign familial Tremor but do see a neurologists these are important things to get evaluated we've got someone in the studio as something like that can they bring it in here for me who's that yeah we could we could bring them in who is that Gamba he's an editor oh yeah but show me I have to ask him questions he may not want to answer no he's working from home though okay all right so I'd have to ask about medication things like that so but in one of these days let's do that let's uh Jeremy what's going on what's going on not much buddy what do you got my name's Jeremy from Southwest Virginia and just had a quick question I've googled this many occasions and I cannot find the answer all right whenever I eat you're not ever but occasionally when I eat sweet things bitter things or sour things sometimes when I drink the right beer I get this acute pain underneath my ear behind my Jawbone sometimes it's almost like a cramping but it's not a cramp yeah dude I'm not the person in my circle who's experienced that what is that what I bet that is you know your parotid gland extends all the way to your ear and I bet that is a contraction of your product your salivary glands right so you eat some sourier glands they go that's that feeling we get when we when we eat something sour the glands constrict and it's possible do you ever get any swelling back there uh not that I've ever known so I would worry that there were maybe could be a stone or some local inflammation or something of the parotid gland you to get that evaluated not that you have to but you you see an ear nose and throat doctor uh because or a head and neck surgeon really is what you'd see because they deal with disorders of the parotid uh and it's you know probably nothing but it's uh congratulations you have a super active salivary glands is that true or maybe underactive could be either way all right all right sorry nah it's good no white brown or anything I'm tired of that stuff uh let's see show me oh let's talk to Shelby oh my Shelby what's going on not a whole lot you there uh yep okay I just wanted to ask you a quick question about uh having Ed after I found out my wife was cheating on me yeah are you at work or something we have to kind of whisper here yeah I'm trying to get to a good spot here okay all right I can always tell when people are trying to make sure no one hears the conversation no you're good you're good all right so I uh yeah I mean I caught her back in sorry sorry what was the situation it's awful uh caught her at the end of June probably uh started seeing someone relatively quickly um I noticed my desire to like watch porn just went to zero which I did Super frequently and if I tried it like nothing with guy on girl it was just like limp dick like not getting hard there's no way like I had to watch either solo stuff or like girl on girl [ __ ] yeah um so the first time I hooked up with my uh go ahead new chick like problems no problems and then all of a sudden I just start getting like intrusive thoughts while we're doing it of course just like right to limp you know what I mean yes of course so so you've been traumatized did you walk in on something was it that kind of trauma no I just had like a really like aching suspicion and then I looked at her phone one morning and then it was just all there you know what I mean pictures the whole [ __ ] thing yeah so you had to see all that I am so sorry then you then you got out of that relationship very quickly or yeah because I was pretty unhappy for years we've been together since we were 19. 12 years when I'm like 31 now you know what I'm saying yeah yeah it just really [ __ ] with me yeah and and why not right why how could it not uh and I I you know if I were you you can kind of go about this two ways uh one is you can maybe get some erectile dysfunction pills uh and sort of push through I've tried that it does work yeah but you can kind of push through and sort of get going get in relationships see if you can sort of calm yourself down and if you can kind of tolerate bring close again with and feeling vulnerable and not having all these crazy thoughts come in but if you can't it really is important to get some treatment here it's and and things like EMDR you know to sort of unwire the trauma can really be helpful but even just sitting and talking with somebody would have kind of dramatic effects I would think and and well you know one of the things you want to know is you know the part part of the stuff you have to work on is you know why did I what did I miss what I let that happen how can I protect myself in the future and then what do I want what do I look for in a person to reduce the risk that that kind of thing would happen again and that having somebody in your corner it's sort of we always describe therapy it's almost like a you know a fighter that goes into the corner and then goes back out to fight having that coach in the corner can really be helpful for you gotcha yeah I'm currently in therapy but okay she's not like the best one I feel like I feel like she agrees like she green lights all of my like bad ideas give me an example of that what's a bad idea ah well personally probably uh falling for this chick so fast you know what I mean like oh it's fine if you know you know and I'm like oh I've been with her for like a month yeah yeah and maybe that's the whole problem maybe weeks after yeah yeah and maybe that maybe falling into something is sort of where you lose the control and stuff again so I I don't know you may be right have you discussed all this with her do you feel comfortable talking about it with my therapist or the girl the therapist the therapist yeah like I've like well also she told me she's leaving the place that I uh see her at like she got a different therapy job so like our last uh session she was just being super blunt with everything which I liked which was like for the first time I always felt like she's like withholding information from me but she was just like like XYZ this is what you need to do and was like kind of giving me advice which you've never done before I I'm not a huge fan of their situation I'm not a I'm not a huge fan of therapists giving advice by the way that's not why you go to therapy I mean they can tell you sort of a how-to but the advice I don't know you have to make your own decisions therapists don't make decisions for you but I get a new therapist maybe some EMDR I don't know how does that how does the chick respond to all this by the way the new one good she's like I know it's not me okay good going through a lot of [ __ ] but I feel like that's a bag of worms in itself because I know that she's been with a lot of people which somebody bugs me sometimes I'm trying to not let it look don't don't I I'm cool you know it's still getting all the way in with somebody so quickly maybe that's just your body and your brain telling you you're not ready you know what I mean just I just think about it that way it's a lot man it's a lot I'm sorry I'm sorry woof we uh huh oh my gosh you you guys will like this you're gonna like this and then we'll go back to more videos of voicemail messages too uh this is Gabby hi Gabby what's going on what's up Dr true how are you I'm good what do you got in your mind so I'm writing a book right now and I thought you'd be the best person to ask but what's the farthest you can amateurally dissect a human body before certain death no anesthesia I mean how do you how do you get a human body to cooperate with surgery right if there's no anesthesia very willing participant maybe restraints but that's not in my notes right now okay so restraints you really just you're just you're just uh stabbing someone essentially uh so this sort of torture it would be torture uh it's hard to say right if you cut an artery and you don't know how to repair it and you can get into that very quickly in in any limb or in in any body cavity so very quickly bleeding to death is a that just can happen anywhere anywhere you go uh that could happen very very quickly uh probably all you could get away with without getting into trouble fast would be just sort of opening the abdominal cavity you could do that um but everything else it seems to me you would get into trouble very very quickly and then eventually not within minutes potentially there will be shock and then shock will lead to death and then in terms of how much you know one of the things about that you should know that my plastic surgeon friends always tell me people always want to have all these plastic surgeries done I want to get the breasts and then I want to do the butt implant and then do the it turns out if you operate a lot on if you do a lot of tissue damage on people they'll just die they just die and we don't even know why they just the body can only tolerate so much tissue damage uh and it's not as much as you think uh and and just dead uh all of a sudden so and and maybe it's sort of shock maybe it's some cardiac arrhythmia maybe it's some circulating uh you know a rhythmogenic thing that affects the heart it's hard to say maybe it's a clotting phenomenon but there's it's the effects that that result in death are very protein when you start doing doing a lot of tissue damage obviously we can operate in a controlled environment when you control bleeding control infection and you can you know limit the tissue damage to a certain extent people can tolerate a fair bit I mean we can replace an aorta I mean we can do that that it's very tough for bodies to get through that and afterwards a lot of supportive care is necessary to get people not to die do you got any more videos for me just out of curiosity yeah I got a couple more uh why did you think we would like that call yeah also I really hope we just assisted with only a book right yeah you should be tracing that call you guys like Macabre but I I went a little more of a cop than I expected so even you guys I understand what won't take that kind of thing well you know what let's do voice messages before we uh go on to more videos let's do some uh how about a substance an addiction voicemail you got it yeah hey what's going on Drew and the other booth boys uh my name is Corey I had a question about ssris as I hear uh you drew bring that up a lot um I I think that the way you talk about how it kills sex drive I think that's the cause of my last two relationships going down in place you see I have no problem beating my meat you know uh you know the phone's right there you know smoke some weed I don't take the Benadryl or nothing but I still have no problem beating the meat but I I didn't want to [ __ ] you know I had really you know great looking significant others but I just did not want to [ __ ] uh when I stopped taking the medication yeah definitely uh still didn't want to [ __ ] so I don't know what's going on because the doctor don't stop taking the medication so what do I do you know do you have any recommendations of which assets all our eyes I should take that might help if they seem to be working like the rest of my life seems great uh any any ideas on what to transition to appreciate it guys stay high and tight and uh it's actually a really serious question and the fact that you continue to have changes in your libido after you come off the SSRI there's a whole world of persistent sexual desire problems and persistent sexual dysfunction from antidepressant medication actually did a whole podcast on this there's a there's there are communities of people that are trying to raise awareness about the fact that not only can you have sexual dysfunction of any type you can have erectile dysfunction desired dysfunction like you're saying you're you kind of can Master it but you can't have really interest in sexuality that is the medication and some people have that persistently even after they come off the medication indefinitely and uh it's it's there's various theories about it one theory is that sort of a neuropathic kind of process but uh be that as it may it's kind of serious uh the one that's the least likely to cause it is Lexapro uh typically you don't want to if you're having this the psychiatrist should get you you first of all should see a psychiatrist and not a primary care doctor and they should get you off office or ssris entirely so it's actually a bigger deal than you might imagine I have a question about this trip yeah um so how much do you think that they are trying to advance medicine in terms of like Pharmacy options like in terms of medication you can take or how much are they just trying to like well we have Lexapro now so let's push that and just deal with the side effects are they trying to develop things without these side effects from the moment this is how how pharmaceutical research works from the moment you pull a molecule off the shelf and identify it you have 10 years to bring it to Market and profit and then you lose the patent ten years from the moment it comes off the shelf on average it takes five years and over a billion dollars to bring a new drug to Market so they're left with five years to make their profit then it goes generic and then it's pennies so they only have five years with these drugs so that that's the only time they push them is during those those years when they can make profit and when there are new things that seem to have new benefits and seem to be better than previous things doctors use them even though they get a little more costly but they have to recoup around somewhere between 800 million and 1.5 billion dollars depending on the drug to that's why the pharmaceutical injury is such a mess because it costs so much money to do the phase three trials and get things through the FDA now the the easiest thing to do is to take a drug you already have and change it a little bit and re retest it for you could do that in a couple of years you know you can get it through the FDA very quickly and that's why there's a million different peps at Xanax tagamets that's why there's a million different Protonix prilosexual Nexium because they're called metoo Drugs That's the most profitable way because then you have eight or nine seven or eight years to make your profits back uh and usually it doesn't cost as much to get it to Market so that's why that happens and then a follow-up question on that um so is there any kind of like conflict of interest or any law or policy that would prevent like one company that's to say they make a drug and it has these side effects can they then make drugs that address those side effects or is that like a conflict of interest that's an interesting question they generally don't in my experience I don't know why usually what happens is a company comes up with a medication that doesn't have the side effects rather than something to treat the side effects and usually what ends up happening is the doctors try are using off label medication to treat the side effects I guess it's probably not profitable to treat site there's not enough people with side effects to make a profit you see what I'm saying yeah I didn't imagine that I mean largely why I got off medication was the side effects and then then it was like trying to balance out the side effects with more drugs and it just seemed like a never-ending kind of yeah but but most of them the more drugs were doctors doing things off label that's not FDA approved or anything and the drug companies didn't bring to Market we just know from research and clinical practice that you can use these things off label all right I'd like a video please and then I want a substance video I want a substance email or a voicemail after that does anyone else have a weird stomach pulse oh let's say you're ordering that's reorder it doesn't hurt but I hate it please it's a reorder I hate the human body it's hysterical that's really funny uh that's because she's you know very very thin wall body wall there and that's her aorta pulsating right right through her skin she's tiny uh and that's okay then this I mean anything we we sometimes worry about that when we see that clinically we always have to kind of feel around the aorta kind of make sure it's not an aneurysm there uh but it's somebody that age it's like unheard of you like guys like that is that that appealing yeah I'm just so freaked out but I mean that happens to me sometimes ah see it's it's not uncommon it really isn't but it's so funny that people get freaked up with their bodies every little thing I have a pulsing question actually oh yeah my uh sometimes it's uh yeah it's a sometimes when actually pretty frequently when I wake up yeah uh if I if my mouth is open I will hear like a tick you know like it sounds like I can hear my heartbeat they're clicking yes and that's like frequent is it a single click or is it click click click it's a pattern yeah or a rhythm yeah uh I don't know you can get clicking in the ear that is your is it in the ear or is it in your throat it's it's definitely in my mouth because I'll I'll close my mouth and I won't hear it I'm like what the [ __ ] and then there's been times I've gone to the like mirror and like looked you know and I'll open my mouth and it's like clear because now it's like an echo you could see it no no no I'm clear the the sound is more clear because I'm in like oh in the bathroom so it's echoing it's and it continues yes can you does your palate move at all uh no no I don't see anything moving I don't see because I I would Rhythm so I would be more convinced I would be more concerned that it's nothing to do with your heartbeat but maybe some sort of spasm of the palette because there you can get fluttering of the palette can cause clicking and funny movements and things and uh so really look at the back of the throat next time that uh next time you you get that I guess I I thought that it had this I thought that it had something to do with the heart um because that also happens after sex if I'll notice that like you know I'm obviously like heart rates up yeah and if I it's you know I can't explain how I figured it out but it's like if my mouth is open I just hear it and it's like if it's like why can somebody else hear it huh Can somebody standing next to you hear it yeah I I I yeah it's got to be your palette It's gotta be something in the back of the palette there and no no like concern there just not really I mean I mean not cardiac concern okay okay um but it's intriguing intriguing yeah definitely weird as hell that sounds like there's a [ __ ] clock inside of me how long you had that for [ __ ] forever yeah yeah yeah so good so say the the Forever part is reassuring right because it means if it were something you would it would declare itself right it would turn into something else it would show itself well I guess I shouldn't say forever I mean it's been like you know I don't know five years or something but it feels like like it's been a long time I just haven't ever it definitely hasn't done anything yeah right no no I I will just tell you though the one weird case I saw of palatal fluttering there's actually something called Butterfly palette look let's look at butterfly palettes even get a video of that you can see that right I think I know what you're talking about yeah yeah yeah yeah but I wonder if this is some form of that something like that uh there's the is that it no no it's a butterfly pattern We're not gonna get it they're giving they're giving color palettes instead of the the mouth of the pharyngeal palette um oh yeah and then now they're looking at uh patterns on the on the mucosa and all right forget we're never gonna see it anyway because you can kind of flutter like that well will you and I'll look it up later all right um give me one more voice message with a a little substance attached to it how about that you can pull up the ingredients and then nicotine pouches and go over them and see if you think they're a uh good substitute for say cigarettes or chewing tobacco thank you love the show bye I I I'm sure you have one under the table a pack of zens really yeah I'm pretty sure tell me why who's using them uh I'm not sure Danny I just saw them there oh yeah maybe yeah Danny I guess wow well that little okay yeah that there we are so you have that there they are oh my God what did he put on here like nicotine gum or something uh uh hmm the print is literally so small it's it it's actually not on here so I'm guessing it's there there's I'm guessing it's just nicotine right uh exactly how what the source is look I'm generally a big fan of nicotine replacement of all types um in fact I always thought they yeah the pouch ingredients uh that people should even think about using if they have a really serious weight problem think about nicotine for weight control even I I am a nicotine fan I don't think nicotine hurts anything I think the obsession people have with you know don't do nicotine no tobacco hurts you tobacco harms you both chewing and smoking that's how you get cancer that's how you get lung disease that's how you get heart disease anything other than tobacco as a source of nicotine I can't think of one that is a problem that gets anywhere near the the dangers of tobacco tobacco happens to have nicotine within it that's what Hooks you on the tobacco but the nicotine is not the problem yes nicotine can increase anxiety nicotine is addictive so what it doesn't cause it cause dependence it's a not really addiction and if you start using these things before the age of 15 you tend to have to need nicotine replacement the rest of your life believe it or not because people just can't tolerate being off with something about nicotinic receptors early in life that they become just geared up in such a way that we just can't tolerate being without nicotine let's see what does it say there contains white powder nicotine other ingredients uh additives filth the other stabilizers we don't even know what that is it's just all additives and sweeteners and things like that I I don't you know I'm assuming it's been properly tested Drew I've had two different dentists tell me that vaping is worse for me than smoking for the teeth they didn't really specify they just said it's worse for me uh absolutely categorically not I don't can't comment on the teeth if they know something about the teeth I don't know I'd be very interested but the there is a panic about vaping vaping is actually the best way we know to get people off cigarettes the most efficacious every study it's always the most effective should you continue vaping no I'd rather you not it's got a bunch of metals and products there is some good data that the government put together that showed over long periods of time maybe pre-cancerous stuff maybe there's some cancer potential there nothing like tobacco nothing not even close not good for you not as bad as tobacco the nicotine not great for you I wouldn't want you to be addicted to it but if it helps you stay away from tobacco I'm all in cause Rhythm disturbances cause anxiety cause sleeplessness that kind of stuff not not super healthy but not a problem not dangerous not medically relevant and people are in this weird Panic about nicotine and it drives me a little nuts so uh thank you all for being here again drafdark gmail.com 818-253-1693 I want to do more voicemails uh I guess I'm going to skip the substance one we want to do it really quickly before I go the voicemail yeah the substance voicemail yeah that was one of them I'll do another one if you want oh that was it the nicotine one yeah all right let's Let it go then that I did I did what I said I was going to do we'll save more for next time appreciate y'all being here we will see you next time all conversations and information exchange during participation of the Doctor Drew after dark podcast or interaction on thedoctor.com website is intended for educational and entertainment purposes only do not confuse this with treatment or physician medical advice or Direction per se you must always follow your medical professionals advice and Direction nothing on these podcasts are posted on this site supplements are supersedes the relationship and direction of your medical caretakers please understand I am not playing the role of physician in this environment per se I'm educating I am a licensed physician with special Awards in American Board of internal medicine and American Board of Education medicine